北京脑科学与类脑研究中心科研开放合作计划创新人才项目---2020年度北脑学者、北脑青年学者的组织工作于2020年5月14日启动，历时3个月，经推荐申报、形式审查、专家评审、公示、主任办公会审定等环节，现将最终入选人员名单公布如下：
1.北脑学者入选人员名单
2.北脑青年学者入选人员名单
按照《北京脑科学与类脑研究中心创新人才、共建平台及科研合作项目管理办法》的规定，北京脑科学与类脑研究中心将与各入选人员及其所在单位在友好协商的基础上签订双聘研究员/青年研究员协议。合作各方将本着优势互补、合作共赢的原则，在学术交流、科研合作、人才培养等方面开展深入交流和密切合作，共同推进北京脑科学与类脑研究的创新发展，为国家科技创新2030-“脑科学与类脑研究”重大项目的实施贡献北京力量。
经北京脑科学与类脑研究中心、北京大学和清华大学专家严格的审核，我中心与生命科学联合中心联合举办的暑期培训班决定录取以下同学。
请被录取同学及时关注自己注册时使用的邮箱，及时确认是否能按时参加培训以及其他相关信息，谢谢。
北京脑科学与类脑研究中心
2020年8月6日
Seminar Type
Lecture Series on Neuropsychiatric Disorders
Preferred Location
Online Zoom Meeting Link: https://zoom.com.cn/j/85328263314?pwd=MWhhb3BQM1QxY0wyK1pmY1ZlVlBaUT09
Meeting ID: 853 2826 3314
Password: 091314
Time
10:00-11:30, Friday, August 7th, 2020
Speaker
Huali Wang, MD, PhD
Professor of Geriatric Psychiatry
Chair, Clinical Research Division
Director, Dementia Care & Research Center
Associate Director, Beijing Dementia Key Lab
Peking University Institute of Mental Health
王华丽 博士
北京大学精神卫生研究所老年精神病学教授、临床研究部主任、老年痴呆护理研究中心主任、北京老年痴呆重点实验室副主任
Host
Dr. Dai Zhang
Topic
Early detection of Alzheimer's disease: research advance and translational implications
阿尔茨海默病早期诊断方法研究进展及临床应用
Abstract
Alzheimer's disease has emerged as a global public health concern. Among the seven themes of the WHO global action plan, early diagnosis and treatment is the key to secure the support for the persons with dementia. However, the etiology of Alzheimer's disease has not been fully elucidated. There are no specific ways of making an early diagnosis. The talk will review the current progress of establishing valid neuropsychological tests, discovering novel biomarkers, and developing optimal algorithms for the early detection of Alzheimer's disease. Besides, how the newly developed approaches might fit the clinical application will be discussed with case demonstration.
Speaker Biography
Dr. Wang obtained Bachelor of Medicine from Peking University (formerly, Beijing Medical University) in 1994, and MD/PhD from Peking University in 2001. She was trained on International Mental Health Research at Harvard Medical School, neuropsychology and neuroimaging of dementia at University of California, Irvine.
Dr. Wang is one of the national pioneers to manage memory clinic and build service capacity for dementia care. She set up the first dementia caregiver support group in China in 2000, developed and tested a community-based family caregiver support program in Beijing. Now she directs a training program for community doctors and service providers, and a train-the-trainer program for dementia caregivers support in China. The care model has been partly adopted by WHO West Pacific Regional Office to develop the toolkit for community-based dementia care in low- and middle-income countries.
Dr. Wang is leading the National Platform on Clinical Dataset and Biobank of Major Mental Disorders. Her research interest included: (1) exploring neuropsychological profiles, blood-based biomarkers and imaging features for early diagnosis of dementia; (2) developing culturally sensitive care for persons with dementia and their caregivers.
Besides, she has joined the panel of the WHO priority setting exercise on dementia research, participated in the advisory board of WHO West Pacific Regional Office to develop the toolkit for community-based dementia care in low and middle-income countries, and has been designated by the National Health Commission as the WHO Global Dementia Observatory Focal Point for China. In addition, Prof. Wang is one of the technical advisers for dementia care and service in National Health Committee. She drafted the National Geriatric Mental Health Plan which was one the key elements of the 13th Five-Year Plan for Health Aging.
我中心与北京大学、协和医学院、南开大学、中国农业大学和首都医科大学联合举办的夏令营，已于7月24日顺利结束。经北京脑科学与类脑研究中心的严格审核，本次夏令营共有17名营员表现出色，获得了“优秀营员”称号，名单如下。
如有异议，请联系010-81912671。
北京脑科学与类脑研究中心
2020年7月31日
处理和呈现（processing and internal representation）奖赏信号是大脑最基本的功能之一。自然奖赏刺激（如饮食、性行为和其他愉悦的感官刺激等）、成瘾性药物和特定脑区的激活可以产生主观的快感、萌发强烈的行为动机并强化相关的学习和记忆。大脑奖赏信号异常导致多种严重的精神疾病，包括快感缺失--抑郁综合症、精神分裂、药物和行为成瘾等。因此，深入探索奖赏信号处理的神经环路与分子机制，对我们理解奖赏行为和相关情绪产生的神经生物学基础，并为相应精神疾病的预防和治疗提供可靠的方案兼具理论和应用意义。
奖赏信号处理是一个涉及多种神经递质（调质）和复杂神经网络的综合过程。在这些递质和调质中间，五羟色胺扮演的角色最为扑朔迷离。五羟色胺（5-hydroxytryptamine; 5-HT）又名血清素（serotonin），是一种由必需氨基酸色氨酸经羟基化和脱羧两步反应生成的含吲哚环的单胺类神经递质。在外周，约占人体90%的五羟色胺主要由肠嗜铬细胞分泌并调节胃肠道功能；而在中枢，绝大多数合成五羟色胺的神经元分布于脑干的中缝核群，并通过其多达7个受体家族约18种亚型来调控感官知觉、运动控制、情绪调节、学习记忆、社会和交配行为、睡眠觉醒和进食代谢等一系列复杂而广泛的生理活动。在这些细胞中，与奖赏密切相关的五羟色胺神经元位于中脑导水管腹侧的中缝背核（dorsal raphe nucleus, DRN）。
近10年来，罗敏敏实验室以转基因小鼠为模型，研究哺乳动物处理奖赏与惩罚的神经环路机制，特别是中缝背核及内侧缰核（medial habenula, MHb）两个脑区及相连的神经环路的作用。研究人员运用电生理和光学成像，从清醒小鼠中记录特定类型神经元在奖赏与惩罚相关行为中的反应特点；继而运用光遗传学及化学遗传学手段，检测激活、抑制和损毁相关神经元对于行为的影响；并利用全细胞膜片钳和光学成像，探索不同药物及细胞信号转导途径在奖赏与惩罚行为中的作用及分子细胞机制。发表了一系列重要的研究论文，建立了新的理论。
在此基础之上，2020年7月10日，罗敏敏研究员受邀在年评（Annual Review of Neuroscience）杂志在线发表题为“Reward Contributions to Serotonergic Functions”的综述文章，系统论述了大脑五羟色胺系统在奖赏信号处理中的重要角色。
文章回顾了自上世纪中叶以来，中枢五羟色胺系统在感觉和情绪信号处理中的研究历史和理论流变，综述了五羟色胺在奖赏三大基本特征（快感、动机和学习）中分别扮演的不同角色；重点介绍了五羟色胺神经元在奖赏相关行为中的实时发放特征和学习机制，在整合比较了传统理论和最新数据的基础上，提出了五羟色胺在奖赏信号处理和行为抉择上的“有益性理论（The Beneficialness Theory of DRN Serotonin）”。该理论确立了DRN五羟色胺编码奖赏而非惩罚的观点，强调了五羟色胺神经元采用相位簇状（phasic）和缓慢张性（tonic）发放的特征分别编码奖赏获取和奖赏期待（等待）的独特模式；并从更广阔的视角引入了学习偶联系数p和代价因子C（cost, C），揭示了DRN五羟色胺神经元动态多维度追踪和衡量外界环境刺激（包括奖赏、惩罚和中性信号）、动物自身需求以及稳态状态，并通过效价和满足计算机制（ valence computation mechanisms and satiety calculation）以独特的发放特征呈现和传播一个综合的“有益性信号”来指导行为决策，最终实现以最小代价获取最大奖赏的目标。
详情请见原文链接：https://www.annualreviews.org/doi/full/10.1146/annurev-neuro-093019-112252
在罗敏敏研究员的领导下，实验室的刘志祥、李毅、周景峰、钟炜欣和张举恩、谭禄彬、王达青、林睿、梁婧文等多届成员分别在五羟色胺奖赏编码、中缝背核功能（奖赏记忆）和缰核—脚间核惩罚信号处理等领域做出了原创性的研究成果。实验室博士后刘志祥和林睿参与了该综述文章的撰写。
一、复试名单
根据《北京脑科学与类脑研究中心2020年夏令营招生通知》的规定与要求，经过严格审核决定同意以下申请者参加北京脑中心-北京大学2020年夏令营复试：
二、复试安排
（一）复试时间
复试时间：2020年7月24日 上午8:30
复试形式：综合面试。复试成绩总分为100分。
复试内容：个人科研经历和成果介绍、对拟从事研究领域的认识、本人拟进行的研究工作设想等。
（二）复试平台
采用网络远程复试的形式，使用腾讯会议系统。
（三）复试安排
1、复试资格审查
鉴于疫情防控需要，对考生复试资格的审查将通过在线核验的形式进行，具体资格审核时间和流程后续将通过邮件通知。对不符合规定或弄虚作假者，一经查实，视为资格审查不通过，取消复试资格。拟录取考生待入学报到时，学院将对其有效身份证件、学历学位证书、学历学籍核验结果等报名材料原件及报考资格进行再次审查，对不符合规定或弄虚作假者，一经查实，取消入学资格。
2、考生复试登录方式
夏令营期间，请考生务必保持电话畅通。考生应在规定时间内登录指定会议室系统，携带本人身份证原件候考，并主动配合考务工作人员完成身份验证核查、周围环境检查和随身物品检查等，并现场签署《诚信复试承诺书》，之后进行复试。
（四）成绩计算方式
1）面试成绩即为复试成绩。
2）面试满分为100分，60分及格，复试成绩及格者择优录取。
（五） 注意事项
1、系统测试安排和在线身份核验：
请考生按要求参加设备及考场环境测试（后续提前邮件和电话通知），并在线完成身份核验，请提前准备好身份证原件，学历学位证书原件，学生证原件以及英语水平证明原件等。
2、如考生未按相关规定的要求参加资格审查或复试的，则视为其主动放弃复试资格。
4、请考生提前打印好《诚信复试承诺书》，以便复试开始之前远程现场签署。
北京脑科学与类脑研究中心
2020年7月15日
一、复试名单
根据《北京脑中心与北京大学联合举办2020年交叉学科优秀大学生夏令营通知》的规定与要求，经过严格审核决定同意以下申请者参加北京脑中心-北京大学2020年夏令营复试：
二、复试安排
（一）复试时间
复试时间：2020年7月23日 上午8:00
复试形式：综合面试。复试成绩总分为100分。
复试内容：个人科研经历和成果介绍、对拟从事研究领域的认识、本人拟进行的研究工作设想等。
（二）复试平台
采用网络远程复试的形式，使用Webex会议系统，腾讯会议系统备用。
（三）复试安排
1、复试资格审查
鉴于疫情防控需要，对考生复试资格的审查将通过在线核验的形式进行，具体资格审核时间和流程后续将通过邮件通知。对不符合规定或弄虚作假者，一经查实，视为资格审查不通过，取消复试资格。拟录取考生待入学报到时，学院将对其有效身份证件、学历学位证书、学历学籍核验结果等报名材料原件及报考资格进行再次审查，对不符合规定或弄虚作假者，一经查实，取消入学资格。
2、考生复试登录方式
夏令营期间，请考生务必保持电话畅通。考生应在规定时间内登录指定会议室系统，携带本人身份证原件候考，并主动配合考务工作人员完成身份验证核查、周围环境检查和随身物品检查等，并现场签署《诚信复试承诺书》，之后进行复试。
（四）成绩计算方式
1）面试成绩即为复试成绩。
2）面试满分为100分，60分及格，复试成绩及格者择优录取。
（五）注意事项
1、系统测试安排和在线身份核验：
请考生按要求参加设备及考场环境测试（后续提前邮件和电话通知），并在线完成身份核验，请提前准备好身份证原件，学历学位证书原件，学生证原件以及英语水平证明原件等。
2、如考生未按学校和院系相关规定的要求参加测试或复试的，则视为其主动放弃复试资格。
4、请考生提前打印好《诚信复试承诺书》，以便复试开始之前远程现场签署。
北京脑科学与类脑研究中心
2020年7月14日
https://virtual-forum2020.kenes.com/en/hall
The Chinese Institute for Brain Research, Beijing (CIBR) was established in March, 2018 by the Beijing Municipal Government and seven institutions in Beijing. Founded to be a pillar of the China Brain Initiative, CIBR aims to support a vibrant interdisciplinary program in neuroscience and its related disciplines, with both basic and applied research focused ultimately on improving human health. CIBR will also take responsibility for coordinating research institutes and managing research programs under the guidance of the China Brain Initiative and Beijing Brain Initiative and making Beijing the world epicenter for neuroscience and brain-inspired computation.
CIBR is now recruiting scientists to lead individual labs and recruiting independent postdoctoral fellows to further their research in a highly innovative and cooperative environment. You are expected to conduct outstanding research in any area of neuroscience or in brain-inspired computing. Applications for positions at multiple levels are welcome.
We are organizing interactive communication meeting in 12th FENS Virtual Forum of Neuroscience on July 11-15th, 2020, which is hosted by the Federation of European Neuroscience Societies (FENS) and organized by the British Neuroscience Association (BNA) at Glasgow (UK).
You can find us by clicking the logo hung in the lobby, or by searching our name by Chinese Institute for Brain Research or CIBR. If you have any question about CIBR and CIBR recruitment, we will be here and waiting for you visit. The link is followed:
https://virtual-forum2020.kenes.com/en/hall
Welcome to join in CIBR and create history here.
Website: http://en.cibr.ac.cn/
Contact: Lubin Tan, PhD (The Assistant to Directors )
Email: PI_recruit@cibr.ac.cn
Cellphone: +86 188 0101 3744
Seminar Type
Lecture Series on Neuropsychiatric Disorders
Preferred Location
Online Zoom Meeting Link: https://zoom.com.cn/j/84603647228?pwd=WG1mcDlQSTBraG85MEsyblFVditvZz09
Meeting ID: 846 0364 7228
Password: 681620
Time
10:00-11:30, Friday, July 17th, 2020
Speaker
Piu Chan, MD, PhD
Professor
Xuanwu Hospital of Capital Medical University
陈彪 博士
首都医科大学宣武医院
教授
Host
Dr. Dai Zhang
Topic
Parkinson's Disease: Critical Issues on Clinical and Translational Research
帕金森病及其临床和转化研究关键问题
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disorders and has become a significant burden to the fast aging society due to its higher prevalence, higher rate of disability and long disease duration. It’s known that PD has a multifactorial etiology and is pathologically characterized by the selective loss of dopaminergic neurons in the substantia nigra due to alpha-synuclein aggregation which also exists in the nerve terminals of multiple body systems. Motor and non-motor symptoms are the cardinal signs presented cross the pre-clinical and clinical stages of the disease. There is no cure so far for PD but many drugs can improve the motor symptoms and quality of life through dopamine replacement therapy. By now, there is no subjective marker for early diagnosis and monitoring disease progression. Current focuses of research mainly include: (1) mechanisms underlying neurodegeneration, (2) biomarkers for early diagnosis and disease progression, (3) neuroplasticity involved in levodopa induced motor fluctuations and deep brain stimulation, and (4) neuron repair and regeneration.
Speaker Biography
Professor Piu Chan (陈彪) graduated from Hunan Medical College in Changsha in 1983 and became a neurologist after the fellowship training. He later acquired his Doctor of Philosophy in neurosciences from Sun Yan-Sen University of Medical Sciences in Guangzhou in 1990 followed by postdoctoral training at the Parkinson's Institute in Sunnyvale, California of USA, where he spent more than 10 years as senior scientist before returning to Beijing in 1998. After return, Dr. Chan had established the Center for Neurodegenerative Diseases and Clinic for Parkinson’s disease which later became part of the Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Research and Clinical Center for Parkinson’s disease of Capital Medical University, Parkinson Disease Center of Beijing Institute for Brain Disorders and Key Laboratory on Parkinson’s Disease of Beijing. Now this center serves more than 40,000 visits of patients with Parkinson’s disease annually.
Dr. Chan is well known for his translational research on neurodegenerative disorders. Collaborating with Dr. Carlie Tanner on several unique cohorts, they were the first reporting that environmental exposures are the major risk factors for Parkinson’s disease in 1980’s. He has worked with Dr. J William Langston on developing non-human primate models of Parkinson’s disease and dyskinesia. By using microwave technology, he first demonstrated that MPTP causes selective energy impairment in the striatum leading to neurodegeneration. He has been studying familial and susceptibility genes and a variety of biomarkers for Parkinson's diseases in a few unique cohorts in China aimed for prediction and prevention of neurodegenerative diseases. He has found the China Parkinson Alliance with more than 550 medical centers and 2000+ neurologists, and the first Virtual Hospital on Parkinson’s disease. He has participated in drafting “MDS Diagnostic Criteria for Parkinson’s Disease” and “MDS Research Diagnostic Criteria for Prodromal Parkinson’s disease”. Dr. Chan’s team has participated in the International LRRK2 Consortium and Apple’s mPower projects. He has been awarded by the China Ministry of Sciences and Technology to establish the National Consortium and Big Data Platform for Parkinson and Alzheimer’s diseases.
Dr. Chan also found the Faculty of Geriatrics of Capital Medical University, the first in China in 2004, and established the Beijing Longitudinal Study on Aging II cohort for investigating Frailty and Neurodegenerative disorders. He has initiated projects investigating the role of polyphenols (funded by M. J. Fox foundation) and Traditional Chinese Medicine in two multi-center trials. He has been the Principal investigator for about 20 Phase I-IV clinical trials. He is an ad hoc consultant for the State Food and Drug Administration of China.
Dr. Chan is currently a Professor and the department head of Neurobiology and Geriatrics and vice director of Neurology in the Xuanwu Hospital of Capital Medical University. He also serves as the Director of National Clinical Research Center for Geriatric Disorders. He has published more than 300 SCI peer-reviewed papers with a citation of 14,770 and h-index 57 in Google Scholar, and about 250 peer-reviewed Chinese papers with a citation of ~10,000 and served as editorial members of more than 15 international journals.
经北京师范大学认知神经科学与学习国家重点实验室审核，我中心与北京师范大学联合招收2020年“申请考核制”博士招生综合考核结果公示名单如下：
如有异议，请联系cibr_student@cibr.ac.cn或010-81912671。
北京脑中心教务部
2020-06-30
实验室简介：
饶毅实验室研究分子神经生物学。
针对动物，我们使用遗传学、分子生物学和生物物理学手段，研究化学递质及受体的化学连接组学/递质组学。我们通过构建一系列敲除递质及其受体的果蝇和啮齿类突变体，研究相应的功能。
通过现代成像技术我们可以在解剖学的层面揭示已知递质的神经环路，我们也可以通过特异的启动子界定的逻辑门在功能上操纵神经环路。我们的化学连接组学/递质组学方法已经发现了调节睡眠和社会行为的部分分子和神经元。有望发现与不同行为对应的神经递质和受体。
针对人类，我们使用遗传学、基因组学和脑成像（fMRI）方法，研究对社会行为和认知重要的基因和脑区。我们的目的是识别出与行为和认知相关脑区所有神经递质和受体。从动物到人机制的保守性使我们可以理解进化中重要的行为。人类特有的机制帮助我们理解我们自身。
详情请参见实验室网站：www.raolab.org
招聘岗位：
实验技术员
招聘要求：
1. 具有生物化学与分子生物学，细胞生物学等相关专业背景的研究生；
2. 具有细胞培养，蛋白表达，纯化经验者优先；
3. 工作认真踏实，动手能力强，积极参与团队研究工作；
4. 对小鼠睡眠及行为研究感兴趣，能稳定工作2年以上。
薪资待遇：
上述岗位属正规劳动合同制聘用人员，享受五险一金，带薪年假，补充医疗保险等福利，薪资根据应聘者的工作能力面谈决定，将为优秀申请人提供有竞争力的薪酬。
应聘方式：
应聘者将本人简历发送到：raolab@126.com
截止日期：
本招聘长期有效，招满即止。
| 友情链接： |
地址：北京市昌平区中关村生命科学园科学园路26号院北京脑科学与类脑研究中心
联系方式： 邮编：102206
Copy right ©2018北京脑科学与类脑研究中心 版权所有 ICP备案号：京ICP备18029179号
Copy right ©2018北京脑科学与类脑研究中心 版权所有 ICP备案号： 京ICP备18029179号
